HYPOXIA AND THE PHENOMENON OF IMMUNE EXCLUSION

Hypoxia and the phenomenon of immune exclusion

Abstract Over the last few years, cancer immunotherapy experienced tremendous developments and it is nowadays considered a promising strategy against many Womens Dresses types of cancer.However, the exclusion of lymphocytes from the tumor nest is a common phenomenon that limits the efficiency of immunotherapy in solid tumors.Despite several mechani

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Structure of Escherichia coli respiratory complex I reconstituted into lipid nanodiscs reveals an uncoupled conformation

Respiratory complex I is a multi-subunit membrane protein complex that reversibly couples NADH oxidation and ubiquinone reduction with proton translocation against transmembrane potential.Complex I from Escherichia coli is among the best functionally characterized complexes, but its structure remains unknown, hindering further studies to understand

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